Risperdal (generic name: Risperidone) is a drug which is prescribed for the treatment of schizophrenia. Also directed for use in patients with depression and bipolar disorder (manic depression), and in children with autism suffering from irritability.
Risperdal (risperidone) is an antipsychotic medicine that works by changing the effects of chemicals in the brain. Risperdal is used to treat schizophrenia in adults and children who are at least 13 years old. Risperdal is also used to treat symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old. Does Risperdal cause any undesirable side effects? Risperdal is also used to treat symptoms of irritability in autistic children who are 5 to 16 years old. What is Risperdal? Dosage Info, Effects, Uses, Interactions.
While you are taking this medicine, you may be more sensitive to extreme temperatures such as very hot or cold conditions. Avoid excessive cooling, overheating or dehydration. Drink plenty of fluids, especially in hot weather and exercise. When you take this medicine, it becomes dangerous to overheat and dehydrate. Risperidone can affect your thinking or reactions. Be careful if you are driving or doing anything that requires you to be on the lookout. Drinking alcohol can exacerbate certain side effects of risperidone. Stop using Risperdal and call your doctor immediately if you have fever, muscle stiffness, confusion, sweating, rapid or uneven heartbeat, restless facial or neck muscle movements, tremor (uncontrollable tremor), swallowing problems, feeling frivolous or fainting.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric.Appropriate studies have not been performed on the relationship of age to the effects of risperidone in children younger than 13 years of age with schizophrenia, in children younger than 10 years of age with bipolar disorder, or in children younger than 5 years of age with autistic disorder. Safety and efficacy have not been established.
Geriatric. Although appropriate studies on the relationship of age to the effects of risperidone have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of risperidone in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving risperidone.
Breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Get emergency medical help if you have signs of an allergic reaction to Risperdal: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Common Risperdal side effects may include:
The dosage of Risperdal should be individualized according to the response and tolerability of the patient. The total daily dose of Risperdal can be administered once daily, or half the total daily dose can be administered twice daily. For patients with body weight less than 20 kg, initiate dosing at 0.25 mg per day. For patients with body weight greater than or equal to 20 kg, initiate dosing at 0.5 mg per day. After a minimum of four days, the dose may be increased to the recommended dose of 0.5 mg per day for patients less than 20 kg and 1.0 mg per day for patients greater than or equal to 20 kg. Maintain this dose for a minimum of 14 days. In patients not achieving sufficient clinical response, the dose may be increased at intervals of 2 weeks or greater, in increments of 0.25 mg per day for patients less than 20 kg, or increments of 0.5 mg per day for patients greater than or equal to 20 kg. The effective dose range is 0.5 mg to 3 mg per day. No dosing data are available for children who weigh less than 15 kg. Once sufficient clinical response has been achieved and maintained, consider gradually lowering the dose to achieve the optimal balance of efficacy and safety. The physician who elects to use Risperdal for extended periods should periodically re-evaluate the long-term risks and benefits of the drug for the individual patient. Patients experiencing persistent somnolence may benefit from a once-daily dose administered at bedtime or administering half the daily dose twice daily, or a reduction of the dose.
Usual Adults Initial Dose
Risperdal can be administered once or twice daily. Initial dosing is 2 mg per day. May increase the dose at intervals of 24 hours or greater, in increments of 1 to 2 mg per day, as tolerated, to a recommended dose of 4 to 8 mg per day. In some patients, slower titration may be appropriate. Efficacy has been demonstrated in a range of 4 mg to 16 mg per day. However, doses above 6 mg per day for twice daily dosing were not demonstrated to be more efficacious than lower doses, were associated with more extrapyramidal symptoms and other adverse effects, and are generally not recommended. In a single study supporting once-daily dosing, the efficacy results were generally stronger for 8 mg than for 4 mg. The safety of doses above 16 mg per day has not been evaluated in clinical trials.
Adults. The initial dose range is 2 mg to 3 mg per day. The dose may be adjusted at intervals of 24 hours or greater, in increments of 1 mg per day. The effective dose range is 1 mg to 6 mg per day, as studied in the short-term, placebo-controlled trials. In these trials, short-term (3 week) anti-manic efficacy was demonstrated in a flexible dosage range of 1 mg to 6 mg per day. Risperdal doses higher than 6 mg per day were not studied.
Pediatrics. The initial dose is 0.5 mg once daily, administered as a single-daily dose in the morning or evening. The dose may be adjusted at intervals of 24 hours or greater, in increments of 0.5 mg or 1 mg per day, as tolerated, to the recommended target dose of 1 mg to 2.5 mg per day. Although efficacy has been demonstrated in studies of pediatric patients with bipolar mania at doses between 0.5 mg and 6 mg per day, no additional benefit was observed above 2.5 mg per day, and higher doses were associated with more adverse events. Doses higher than 6 mg per day have not been studied.